alexa [Relationship between blast crisis of chronic myeloid leukemias and abnormality of p16 and calcitonin genes].
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Xu D, Hong W, Wang S

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Abstract OBJECTIVE: To study the relationship between homozygous deletions of p16 gene and calcitonin hypermethylation and chronic myeloid leukemia (CML) blast crisis. METHODS: Semiquantitative multiplex polymerase chain reaction (PCR) was used to detect homozygous deletions of p16 gene and semiquantitative PCR to detect calcitonin gene hypermethylation in 53 CML patients. RESULTS: In 53 CML patients, homozygous deletion of p16 gene was found in none of them in chronic phase, while in 6.3\% (1/16) of them in myeloid blast crisis, 66.7\% (8/12) in lymphoid blast crisis, and 2/5 (40\%) in mixed cell blast crisis. Calcitonin gene hypermethylation was found in 10\% (2/20), 68.8\%(11/16), 16.7\%(2/12), and 40\% (2/5), respectively. CONCLUSION: There is intimate relationship between homozygous deletions of p16 gene and CML in lymphoid blast crisis, between calcitonin gene hypermethylation and CML in myeloid blast crisis. Moreover, abnormality of both genes may be associated with mixed cell blast crisis in CML patients. Simultaneous detection of the two genes help early pickup CML patients in blast crisis.
This article was published in Zhonghua Zhong Liu Za Zhi and referenced in Journal of Cytology & Histology

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