Author(s): Funakoshi Y, Omori H, Yada H, Katoh T
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Abstract A longitudinal study was conducted to investigate the relation between the changes of bone mineral density (BMD) over a seven-year period and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene or lifestyle factors. The subjects were 113 premenopausal female employees from a large-scale integrated manufacturing facility in Japan aged 25.6 ± 4.2 years (mean ± standard deviation) at baseline. BMD was measured at the radius by dual energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire. The genotype frequencies of LRP5 gene polymorphism were 52\%, 39\%, and 9\% for AA, AV, and VV, respectively. After seven years, BMD showed a significant decrease (from 0.463 ± 0.045 to 0.456 ± 0.046 g/m²) in subjects with the AV or VV genotypes, but not in subjects with the AA genotype. Analysis of covariance with adjustment for age and body mass index showed that subjects who drank alcohol displayed a significantly greater change of BMD if they had the AV or VV genotype than if they had the AA genotype (F=4.547, p=0.036). Investigation of LRP5 A1330V polymorphism may be useful for identifying individuals who are susceptible to osteoporosis, allowing early preventive measures to be provided.
This article was published in Asia Pac J Clin Nutr
and referenced in Journal of Osteoporosis and Physical Activity