Author(s): Yaturu S, Rains J, Jain SK
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Abstract AIM: Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels. METHODS: In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined. RESULTS: OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha. CONCLUSION: OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.
This article was published in Cytokine
and referenced in Biochemistry & Physiology: Open Access