alexa Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size.
Chemical Engineering

Chemical Engineering

Journal of Chemical Engineering & Process Technology

Author(s): Sebhatu T, Alderborn G

Abstract Share this page

Abstract The aim of this study was to experimentally evaluate an equation for describing tablet tensile strength by studying relationships between the measured tensile strength and the calculated effective interparticulate contact area in tablets prepared from varying size fractions of amorphous and crystalline lactose at varying pressures. Amorphous lactose produced tablets of higher tensile strength than crystalline lactose and there was a tendency for reduced particle size to increase tablet strength. The tablet tensile strength correlated reasonably well with the effective area of contact for each material after compensation for a particle size-related intercept. It was thus concluded that the tensile strength equation under investigation reflects a structural property of the tablet which correlates with the tensile strength of the tablet. The slope of the tensile strength-contact area relationship differed between the materials and original particle size also had a small effect on this parameter. The results indicate thus also that the differences in compactability between amorphous and crystalline lactose are mainly the result of differences in bonding capacity, although differences in particle deformability also play a limited part.
This article was published in Eur J Pharm Sci and referenced in Journal of Chemical Engineering & Process Technology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version