alexa Remote loading of preencapsulated drugs into stealth liposomes.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Sur S, Fries AC, Kinzler KW, Zhou S, Vogelstein B

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Abstract Loading drugs into carriers such as liposomes can increase the therapeutic ratio by reducing drug concentrations in normal tissues and raising their concentrations in tumors. Although this strategy has proven advantageous in certain circumstances, many drugs are highly hydrophobic and nonionizable and cannot be loaded into liposomes through conventional means. We hypothesized that such drugs could be actively loaded into liposomes by encapsulating them into specially designed cyclodextrins. To test this hypothesis, two hydrophobic drugs that had failed phase II clinical trials because of excess toxicity at deliverable doses were evaluated. In both cases, the drugs could be remotely loaded into liposomes after their encapsulation (preloading) into cyclodextrins and administered to mice at higher doses and with greater efficacy than possible with the free drugs.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Nanomedicine & Nanotechnology

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