alexa Renal allograft calcification -- prevalence and etiology in pediatric patients.


Journal of Transplantation Technologies & Research

Author(s): Habbig S, Beck BB, Feldktter M, Krber F, Laffeber C,

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Abstract BACKGROUND: Calcification of renal allografts has been reported in adult kidney transplant (KTx) recipients with a widely differing prevalence (2-60\%). Persistent hyperparathyroidism, hypercalcemia and concomitant hypercalciuria were identified as major risk factors. We aimed to determine the prevalence and risk factors for such calcifications in children. METHODS: We investigated histological stains of routine graft biopsies from pediatric KTx patients for renal calcifications and determined the urinary excretion of lithogenic (oxalate, calcium) and stone-inhibitory substances (citrate). RESULTS: In our series of transplant patients, tubular calcification was found in 16 of the 36 (44.4\%) KTx biopsies by an additional Kossa stain. This transplant calcification was not associated with any singular risk factor and was not correlated to a worse transplant outcome. CONCLUSION: Although our pediatric findings confirm the reported incidence rates of KTx calcification in adults, we could neither identify hypercalciuria as a risk factor nor confirm any negative influence on graft function. However, long-term studies are clearly needed to prove or disprove a negative impact of calcifications on graft function. Copyright 2009 S. Karger AG, Basel. This article was published in Am J Nephrol and referenced in Journal of Transplantation Technologies & Research

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