alexa Renal autoregulation and vulnerability to hypertensive injury in remnant kidney.
Surgery

Surgery

Medical & Surgical Urology

Author(s): Bidani AK, Schwartz MM, Lewis EJ

Abstract Share this page

Abstract The remnant kidney model is characterized by moderate hypertension, proteinuria, and progressive glomerular scarring, which are ameliorated by a low-protein diet or antihypertensive drugs. The role of renal autoregulation, in determining vulnerability to hypertensive injury was investigated. After right nephrectomy and infarction of two-thirds of the left kidney, rats were fed an isocaloric normal (NP) or low-protein (LP) diet. After 3-4 wk blood pressure was not significantly different between NP and LP rats (171 +/- 8 vs. 155 +/- 6 mmHg), but urinary protein excretion was higher in NP rats (32.3 +/- 7.3 vs. 7.0 +/- 1.2 mg/24 h P less than 0.05). Measurement of renal plasma flow and glomerular filtration rate (GFR) after graded changes in renal perfusion pressure (100-160 mmHg) demonstrated poor autoregulation in NP but not in LP rats. Morphological evidence of severe injury in the form of fibrinoid necrosis and thrombosis of arterioles and glomeruli was largely confined to NP rats and became more severe after 6-8 wk. We conclude that remnant kidney rats fed NP diet autoregulate poorly, which may account for the malignant hypertensive injury to "unprotected" glomeruli, despite only moderate systemic hypertension, and contribute to the progressive nephron loss that is encountered.
This article was published in Am J Physiol and referenced in Medical & Surgical Urology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords