alexa Renal histopathological changes in the goldfish (Carassiusauratus) after sublethal exposure to hexachlorobutadiene


Toxicology: Open Access

Author(s): Renate Reimschuessel, Richard O Bennett, Eric B May, Michael M Lipksy

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Hexachlorobutadiene (HCBD), a chlorinated hydrocarbon, is an acute renal toxicant in mammals. Goldfish (Carassius auratus) were given a single i.p. injection of a sublethal dose (500 mg/kg) of HCBD and sampled daily for one week. No damage was observed by light microscopy 6 h post injection. At 24 h, however, cytoplasmic vacuolation and necrosis occurred in the renal tubules. This damage was localized to the epithelium of the second (P2) and third (P3) segments of the proximal tubule. The damage persisted for seven days. By the sixth day the first segment (P1) of the proximal tubule had small cytoplasmic vacuoles. The ratio of kidney to body weight was significantly greater in the treated fish on the fourth day. Gamma glutamyl transpeptidase (GGT), a histochemical marker of proximal tubule brush border in mammals, was demonstrated in the goldfish kidney. Intense staining was noted only in P2 and P3. GGT staining was also present in the lumen of the damaged, vacuolated tubules of HCBD-treated fish.

This article was published in Aquatic Toxicology and referenced in Toxicology: Open Access

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