alexa Renal protective effects of amlodipine on partially nephrectomized spontaneously hypertensive rats fed a high-salt diet.


Medical & Surgical Urology

Author(s): Kanno Y, Suzuki H, Okada H, Saruta T

Abstract Share this page

Abstract We examined the effects of a calcium-channel blocker amlodipine on progression of renal failure in 5 of 6 nephrectomized spontaneously hypertensive rats (SHR) fed a high-salt diet. Twelve SHR, 5 of 6 with nephrectomy and salt-loading, were divided into two group: group 1 as control (n = 6) and group 2 treated with 2 mg/kg/day amlodipine (n = 6). During the 10 study weeks, body weight, systolic blood pressure (SBP), and daily urinary protein excretion were measured every 2 weeks. At the end of the study, serum creatinine, urea nitrogen, and total protein and albumin were determined. Renal tissues were obtained for light microscopic examination. The increase in SBP after 10 study weeks was significantly less in the treated group than in the control group (control 287 +/- 5 mm Hg; amlodipine 237 +/- 23 mm Hg (p < 0.01)). Urinary protein excretion was also suppressed in the amlodipine-treated group (p < 0.01). Although in the control group glomerular sclerosis and hyalinosis were marked, they were significantly less in the amlodipine-treated group. These results illustrate that amlodipine can attenuate BP increase and inhibit progression of hypertensive renal injury in this rat model.
This article was published in J Cardiovasc Pharmacol and referenced in Medical & Surgical Urology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version