alexa RenalGuard System for the prevention of acute kidney injury in patients undergoing transcatheter aortic valve implantation.


Journal of Kidney

Author(s): Visconti G, Focaccio A, Donahue M, Golia B, Marzano A,

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Abstract AIMS: We aimed to assess whether the RenalGuard™ System is effective in preventing acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: Forty-eight consecutive patients with chronic kidney disease (CKD) scheduled for TAVI were assigned to: 1) hydration with sodium bicarbonate solution (Control group), or 2) hydration with RenalGuard Therapy (RenalGuard group). Hypotension was defined as periprocedural mean blood pressure <55 mmHg. The primary endpoint was the occurrence of AKI (i.e., an increase of ≥0.3 mg/dL in the serum creatinine concentration at seven days). AKI occurred in 10/26 (38.5\%) patients in the Control group and in 1/22 (4.5\%) patients in the RenalGuard group (p=0.005, odds ratio [OR] 0.076, 95\% confidence interval [CI]: 0.009-0.66). RenalGuard Therapy protected against AKI (OR 0.71, 95\% CI: 0.07-0.775, p=0.026), whereas post-procedural hypotension (OR 3.88, 95\% CI: 1.06-14.24, p=0.040), and contrast media volume (OR 3.65, 95\% CI: 1.15-5.75, p=0.043) increased the risk of AKI. CONCLUSIONS: This non-randomised pilot study suggests that RenalGuard Therapy may be effective in preventing AKI in CKD patients undergoing TAVI. This article was published in EuroIntervention and referenced in Journal of Kidney

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