alexa Repigmentation by outer-root-sheath-derived melanocytes: proof of concept in vitiligo and leucoderma.


Journal of Clinical & Experimental Dermatology Research

Author(s): Vanscheidt W, Hunziker T, Vanscheidt W, Hunziker T

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Abstract BACKGROUND: Treatment of depigmented skin is an unmet medical need. OBJECTIVE: Melanocytes or stem cells thereof residing in the outer root sheath (ORS) of hair follicles might be used to repigment skin. METHODS: After de-epidermisation, autologous ORS cell solutions were applied to 5 patients with vitiligo and 1 with leucoderma. RESULTS: Stable repigmentation in a variable percentage was documented in all the patients. CONCLUSION: Applying ORS-derived melanocytes is a promising technology to improve autologous melanocyte transplantation. Copyright 2009 S. Karger AG, Basel. This article was published in Dermatology and referenced in Journal of Clinical & Experimental Dermatology Research

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