Author(s): Lamine A, CaumontSarcos A, Chaix ML, SaezCirion A, Rouzioux C, , Lamine A, CaumontSarcos A, Chaix ML, SaezCirion A, Rouzioux C,
Abstract Share this page
Abstract The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
This article was published in AIDS
and referenced in Journal of AIDS & Clinical Research