alexa Reported adverse event cases of methemoglobinemia associated with benzocaine products.


Emergency Medicine: Open Access

Author(s): Moore TJ, Walsh CS, Cohen MR

Abstract Share this page

Abstract BACKGROUND: Methemoglobinemia (MHb) is characterized by abnormal levels of oxidized hemoglobin that cannot bind and transport oxygen. When induced by benzocaine anesthetic spray and other chemicals, it can result in cyanosis and life-threatening complications. METHODS: From 818 439 adverse event reports received by the US Food and Drug Administration from November 1997 through March 2002, we extracted every report for use of a benzocaine product. We classified each case by product type (eg, spray, gel, or solution), by whether MHb was involved, and by the dose given. RESULTS: Among 198 reported adverse events of all types associated with benzocaine, 132 cases (66.7\%) involved definite or probable MHb. The MHb cases included 107 serious adverse events (81.1\%) and 2 deaths (1.5\%). In 123 cases (93.2\%), the product was a spray; in 2 cases (1.5\%), a benzocaine-containing lozenge; and 1 case, a gel. In the 69 cases that specified a dose, 37 (53.6\%) indicated that a single spray was applied (approximately the recommended amount). CONCLUSIONS: Health professionals involved in endoscopy, intubation, bronchoscopy, or similar invasive procedures using benzocaine-containing sprays should know that (1) administration may cause MHb with potentially serious consequences, (2) identifying the reaction to benzocaine usually requires cooximetry (although it can be implied by symptoms), and (3) treatment involves immediate intravenous administration of 1 to 2 mg/kg of methylene blue. This article was published in Arch Intern Med and referenced in Emergency Medicine: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version