alexa Reproductive and menopausal factors and risk of systemic lupus erythematosus in women.


Journal of Bacteriology & Parasitology

Author(s): Costenbader KH, Feskanich D, Stampfer MJ, Karlson EW

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Abstract OBJECTIVE: Systemic lupus erythematosus (SLE) occurs predominantly in women, and hormones may play a role in its etiology. This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE. METHODS: A cohort of 238,308 women was prospectively examined. Subjects were older women (ages 30-55 years at start) and younger women (ages 25-42 years at start) from the Nurses' Health Study (NHS) and NHSII cohorts. Incident SLE diagnosed between 1976 and 2003 was confirmed by medical record review. The relative risk (RR) of SLE was estimated separately in each cohort using Cox proportional hazards models, and then pooled using meta-analysis random effects models. RESULTS: Two hundred sixty-two incident cases of SLE were confirmed among the women. In multivariable models adjusted for reproductive and other risk factors, age
  • DOI: 10.1002/art.22510
  • This article was published in Arthritis Rheum and referenced in Journal of Bacteriology & Parasitology

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