alexa Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): LoiselMeyer S, Jimnez de Bags MP, Bassres E, Dornand J, Khler S,

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Abstract A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication within nitric oxide-producing murine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence.
This article was published in Infect Immun and referenced in Journal of Bioterrorism & Biodefense

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