alexa Respiratory reactions provoked by double-blind food challenges in children.


Journal of Allergy & Therapy

Author(s): James JM, BernhiselBroadbent J, Sampson HA

Abstract Share this page

A total of 320 children with atopic dermatitis undergoing double-blind, placebo-controlled food challenges (DBPCFC) for the evaluation of food hypersensitivity were monitored for respiratory reactions. The patients, ages 6 months to 30 yr, were highly atopic (median IgE; 3,400 IU/ml) and had multiple sensitivities to foods and aeroallergens. Fifty-five percent of the patients had asthma; 45% presented with both asthma and allergic rhinitis. Food hypersensitivity was confirmed by DBPCFC in 205 (64%) of the 320 patients evaluated, and 121 (59%) of these 205 patients experienced respiratory reactions, including nasal, laryngeal, and/or pulmonary symptoms in 34 (17%). To assess the degree of pulmonary dysfunction developing during food hypersensitivity reactions, especially those including lower respiratory symptoms, 88 of these patients were monitored with spirometry during positive and negative DBPCFC. Of these patients, 13 (15%) developed lower respiratory symptoms, including wheezing, during DBPCFC; however, only six patients had a > 20% decrease in FEV1. We conclude that respiratory symptoms are commonly provoked in children with atopic dermatitis during DBPCFC, but significant bronchopulmonary obstruction is not frequently observed.

This article was published in Am J Respir Crit Care Med. and referenced in Journal of Allergy & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version