alexa Response of the border zone to myocardial infarction in rats.

Journal of Autacoids and Hormones

Author(s): Olivetti G, Ricci R, Beghi C, Guideri G, Anversa P

Abstract Share this page

Abstract The response of the surviving myocardium 30 days after coronary artery occlusion was measured morphometrically in the regions bordering and remote from infarcts of different sizes. Mean cell volume per nucleus increased with infarct size in both zones, but the rate of change was greater in the border than in the remote portion of the unaffected myocardium. Capillary numerical density within the uninjured tissue progressively decreased with infarct size leading to an increased diffusion distance for oxygen. Although the magnitude of changes in capillary density was similar in the two regions of the ventricle, the analysis of the individual values in each heart showed that in infarcts comprising more than 11\% of the ventricular wall capillary concentration and the path length for oxygen supply to the myocytes were affected more in the border zone than in the myocardium remote from the scar. In conclusion, the border zone participates in the hypertrophic recovery process after infarction, but the inadequate growth of the capillary microvasculature suggests that this region is more susceptible to additional ischemic episodes.
This article was published in Am J Pathol and referenced in Journal of Autacoids and Hormones

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords