alexa Response surface methodology for the optimization of kojic acid production by Aspergillus flavus using Palmyra sap as a carbon source


Fermentation Technology

Author(s): Veerendra Kumar Bapatla

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The present investigation was planned to conduct for obtaining enhanced yields of kojic acid by using response surface methodology. Initially OFAT strategy was applied to study the effect of seven different macro-micro elements on growth and out of seven variables screened, five factors Substrate concentration, Peptone concentration, Time, Temperature, pH were highly influential in favoring the production rate. In the subsequent step, these factors were furthermore optimized using central composite design and response surface analysis. From the multiple regression analysis of the experimental data, a second order polynomial model was resolved. The maximum kojic acid production obtained was 78.6 g/L under static, surface fermentation conditions at an optimized level of Substrate concentration (100 g/L), Peptone concentration (3 g/L), pH (4.0), Incubation time (32d), and Temperature (28 0 C). It was evaluated from the model that the determination co-efficient was (R2 =0.9561) denoted that 95.61% of the variability in the response could be interpreted by the model.

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This article was published in European Journal of Biotechnology and referenced in Fermentation Technology

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