alexa Responsiveness of patients with advanced ovarian carcinoma to tamoxifen. A Gynecologic Oncology Group study of second-line therapy in 105 patients.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Hatch KD, Beecham JB, Blessing JA, Creasman WT

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Abstract One hundred five patients with Stage III or IV epithelial ovarian cancer whose disease had persisted or recurred after primary surgery and first-line chemotherapy were given tamoxifen (20 mg orally twice daily) and evaluated for response. Eighteen percent of the patients responded: 10\% demonstrated a complete response (CR) and 8\% showed a partial response (PR). Thirty-eight percent of the patients had short-term disease stabilization. CR had a median duration of 7.5 months, with the longest lasting 17 months. For patients with PR or stable disease, the median duration of response was 3 months (maximum duration, 9 months). When estrogen receptors of tumor tissue from patients demonstrating CR were evaluated, eight of nine (89\%) had elevated estrogen receptor levels. This contrasts with patients who had stable or progressive disease as only 59\% of them had measurable estrogen receptors (P = 0.16).
This article was published in Cancer and referenced in Journal of Molecular and Genetic Medicine

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