alexa Rethinking clinical trials for cytostatic drugs.
Pharmaceutical Sciences

Pharmaceutical Sciences

Advances in Pharmacoepidemiology and Drug Safety

Author(s): Millar AW, Lynch KP

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Abstract The failure of many cytostatic agents in Phase III clinical trials for treatment of common cancers has led researchers to question current approaches to trial development. Recent studies offer some clues as to what is wrong with two particular aspects of clinical trial design--survival as an end point and simultaneous combination with cytotoxic chemotherapy--and indicate possible alternatives. This article was published in Nat Rev Cancer and referenced in Advances in Pharmacoepidemiology and Drug Safety

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