Author(s): Yardeni T, Eckhaus M, Morris HD, Huizing M, HoogstratenMiller S
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Abstract Intravenous vascular access is technically challenging in the adult mouse and even more challenging in neonatal mice. The authors describe the technique of retro-orbital injection of the venous sinus in the adult and neonatal mouse. This technique is a useful alternative to tail vein injection for the administration of non-tumorigenic compounds. The authors report that they have routinely used this technique in the adult mouse to administer volumes up to 150 μl without incident. Administration of retro-orbital injections is more challenging in neonatal mice but can reliably deliver volumes up to 10 μl.
This article was published in Lab Anim (NY)
and referenced in Journal of Blood Disorders & Transfusion