alexa Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): Bergman H, Wichmann T, DeLong MR

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Although it is known that Parkinson's disease results from a loss of dopaminergic neurons in the substantia nigra, the resulting alterations in activity in the basal ganglia responsible for parkinsonian motor deficits are still poorly characterized. Recently, increased activity in the subthalamic nucleus has been implicated in the motor abnormalities. To test this hypothesis, the effects of lesions of the subthalamic nucleus were evaluated in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The lesions reduced all of the major motor disturbances in the contralateral limbs, including akinesia, rigidity, and tremor. This result supports the postulated role of excessive activity in the subthalamic nucleus in Parkinson's disease.

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This article was published in Science and referenced in Journal of Clinical Research & Bioethics

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