alexa RhBMP-2 alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration.



Author(s): Wikesj UM, Sorensen RG, Kinoshita A, Wozney JM

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Abstract BACKGROUND: Recombinant human bone morphogenetic protein 2 (rhBMP-2) in a carrier has been shown to induce significant bone formation. Several candidate carriers, however, lack structural integrity to offset compressive forces that may compromise rhBMP-2 bone induction, in particular, for challenging onlay indications such as alveolar ridge augmentation. PURPOSE: The objective of this study was to evaluate rhBMP-2 in a calcium-phosphate cement carrier, alphaBSM, for vertical alveolar ridge augmentation and immediate dental implant osseointegration. MATERIALS AND METHODS: Six adult Hound Labrador mongrels with 5 mm critical size supra-alveolar peri-implant defects were used. Three animals received rhBMP-2/alphaBSM (rhBMP-2 at 0.40 and 0.75 mg/mL) in contralateral jaw quadrants (total implant volume/defect approximately 1.5 mL). Three animals received alphaBSM without rhBMP-2 (control group). The animals were euthanized at 16 weeks post surgery, and block biopsies were processed for histologic and histometric analysis. RESULTS: rhBMP-2/alphaBSM induced substantial augmentation of the alveolar ridge. Control sites exhibited limited new bone formation. Vertical bone augmentation averaged (+/- SD) 4.9 +/- 1.0 mm (rhBMP-2 at 0.40 mg/mL), 5.3 +/- 0.3 mm (rhBMP-2 at 0.75 mg/mL), and 0.4 +/- 0.4 mm (control); new bone area 8.5 +/- 4.2 mm2, 9.0 +/- 1.9 mm2, and 0.5 +/- 0.4 mm2; new bone density 55.1 +/- 6.4\%, 61.1 +/- 6.0\%, and 67.7 +/- 9.5\%; and new bone-implant contact 26.9 +/- 17.5\%, 28.5 +/- 1.4\%, and 24.6 +/- 16.1\%, respectively. Residual alphaBSM comprised < 1\% of the new bone. Bone density for the contiguous resident bone ranged from 65 to 71\%, and bone-implant contact ranged from 49 to 64\%. CONCLUSIONS: Surgical implantation of rhBMP-2/alphaBSM appears an effective protocol for vertical alveolar ridge augmentation procedures and immediate dental implant osseointegration and for onlay indications of lesser complexity.
This article was published in Clin Implant Dent Relat Res and referenced in Dentistry

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