alexa Risk factors for severe Rift Valley fever infection in Kenya, 2007.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Anyangu AS, Gould LH, Sharif SK, Nguku PM, Omolo JO,

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Abstract A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study to define risk factors associated with infection and severe disease. A total of 861 individuals from 424 households were enrolled. Two hundred and two participants (23\%) had serologic evidence of acute RVF infection. Of these, 52 (26\%) had severe RVF disease characterized by hemorrhagic manifestations or death. Independent risk factors for acute RVF infection were consuming or handling products from sick animals (odds ratio [OR] = 2.53, 95\% confidence interval [CI] = 1.78-3.61, population attributable risk percentage [PAR\%] = 19\%) and being a herds person (OR 1.77, 95\% CI = 1.20-2.63, PAR\% = 11\%). Touching an aborted animal fetus was associated with severe RVF disease (OR = 3.83, 95\% CI = 1.68-9.07, PAR\% = 14\%). Consuming or handling products from sick animals was associated with death (OR = 3.67, 95\% CI = 1.07-12.64, PAR\% = 47\%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors.
This article was published in Am J Trop Med Hyg and referenced in Journal of Vaccines & Vaccination

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