Author(s): Giacometti A, Cirioni O, Gov Y, Ghiselli R, Del Prete MS,
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Abstract Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of Microbial & Biochemical Technology