Author(s): Nudler E
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Abstract RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking--the reversible sliding of RNA polymerase along DNA and RNA--has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability. Copyright © 2012 Elsevier Inc. All rights reserved.
This article was published in Cell
and referenced in Cloning & Transgenesis