Author(s): Hutvgner G, Zamore PD
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Abstract In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.
This article was published in Curr Opin Genet Dev
and referenced in Journal of Next Generation Sequencing & Applications