alexa Role of a KIR HLA-C allorecognition system in pregnancy.
Immunology

Immunology

Journal of Immunobiology

Author(s): VarlaLeftherioti M

Abstract Share this page

Abstract Decidual natural killer (NK) cells are thought to play a significant role in the allorecognition mechanisms during pregnancy. Through their activating and inhibitory receptors they may recognize selectively class I HLA alleles expressed on invading trophoblast and provide self-signals to control NK responses, thus regulating the maternal immune response at the fetomatenal interface. Killer immunoglobulin-like receptors (KIR) constitute one of the families of class I MHC receptors which are expressed on NK cells. Their repertoire includes both activating and inhibitory receptors, most of which recognize specific epitopes on HLA-C molecules and can either activate NK cell responses or abort activating signals and inhibit NK cell functions. Since KIRs are expressed on decidual NK cells and the HLA-C molecules that they recognize are also expressed on invading trophoblast, KIR receptors may play a regulatory role in pregnancy by interacting with their trophoblastic HLA-C counterparts and providing trophoblast damage evading signals (KIR/HLA-C allorecognition system). Our hypothesis that the KIR/HLA-C system might be ineffective in some unsuccessful pregnancies, has been investigated in women with unexplained spontaneous abortions. Our results suggest that a limited maternal repertoire of inhibiting KIRs (inhKIRs) and/or lack of maternal inhKIR-fetal HLA-C epitope matching may predispose to miscarriage. This article was published in J Reprod Immunol and referenced in Journal of Immunobiology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version