alexa Role of alkyl substitution in 2,3-disubstituted and 3-substituted 4-quinazolones on the inhibition of pyruvic acid oxidation
Microbiology

Microbiology

Journal of Chemical Biology & Therapeutics

Author(s): Parmar SS, Kishor K, Seth PK, Arora RC

Abstract Share this page

Several 2,3-disubstituted and 3-substituted 4-quinazolones have been synthesized to investigate structure-activity relationship of these quinazolones with respect to their ability to inhibit pyruvic acid oxidation by rat brain homogenate. 2-Methyl-3-(o-tolyl)-4-quinazolone was used for comparison. In general 2,3-disubstituted quinazolones exhibited greater inhibitory properties as compared to the coresponding 3-substituted quinazolones Introduction of the alkyl substituent(s) on the phenyl nucleus, attached to the 3 position of the quinazolone molecule, significantly influenced the enzyme inhibitory properties of these quinazolones. In both series, maximum inhibition of the oxidation of pyruvic acid was observed with quinazolones synthesized from 2,4-dimethylaniline. Increase in the concentration of the quinazolones simultaneously increased the enzyme inhibition Added NAD, responsible for the increase in the respiratory activity of brain homogenate during oxidation of pyruvic acid, reduced the inhibition produced by 2,3-disubstituted and 3-substituted 4-quinazolones.

This article was published in J Med Chem and referenced in Journal of Chemical Biology & Therapeutics

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords