Author(s): Yeniyol CO, Sorguc S, Minareci S, Ayder AR
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Abstract OBJECTIVES: To determine the effectiveness of intravenously administered interferon-alpha-2B for the prevention of testicular atrophy in postpubertal men with mumps orchitis. METHODS: Eighteen patients with mumps orchitis were evaluated. The patients were hospitalized, and 3 x 1,000,000 IU intravenous interferon-alpha-2B was administered daily for a total of 7 days. All patients were evaluated by testicular biopsy on the 12th month after interferon treatment. RESULTS: Biopsy results demonstrated total atrophy of the seminiferous tubules in seven (38.8\%), 10\% atrophy in three (16.6\%), and no apparent histopathologic alterations except an arrest in spermatogenesis in eight (44.6\%) testes. CONCLUSIONS: Systematic treatment with interferon-alpha-2B does not seem completely effective in preventing testicular atrophy after mumps orchitis. Further investigations involving larger populations are needed.
This article was published in Urology
and referenced in Reproductive System & Sexual Disorders: Current Research