alexa ROLE OF MATERNAL IMMUNOGLOBULINS BLOCKING TSH-INDUCED THYROID GROWTH IN SPORADIC FORMS OF CONGENITAL HYPOTHYROIDISM
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Thyroid Disorders & Therapy

Author(s): RD Van Der Gaag, HA Drexhage, JH Dussault

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Among 34 mothers of infants with sporadic congenital hypothyroidism detected in the Quebec screening programme, 15 had immunoglobulins blocking thyroid growth induced by thyroid-stimulating hormone (TSH) when tested in the sensitive Feulgen cytochemical bioassay. At the time of delivery all the mothers were clinically and biochemically euthyroid, and in general the growth-blocking immunoglobulins were found in the absence of thyroid antimicrosomal antibodies. 2 mothers, however, had significant titres of antimicrosomal antibodies. They became hypothyroid 1 and 3 years after delivery. 8 of 16 post-partum infant blood samples were positive for immunoglobulins blocking TSH-induced thyroid growth. 4 of 7 positive mothers tested up to 3 years after delivery had become negative, thus indicating a trend for these immunoglobulins to disappear from the maternal circulation. Thus, transplacental passage of maternal immunoglobulins influencing TSH-induced processes of thyroid growth may play a part in the pathogenesis of sporadic congenital hypothyroidism.

This article was published in Lancet and referenced in Journal of Thyroid Disorders & Therapy

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