Author(s): Brown KE, Freeman GJ, Wherry EJ, Sharpe AH
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Abstract While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated. Copyright 2010 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Immunol
and referenced in Journal of Clinical & Cellular Immunology