alexa Role of Staphylococcus protease in the development of influenza pneumonia.
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): Tashiro M, Ciborowski P, Klenk HD, Pulverer G, Rott R, Tashiro M, Ciborowski P, Klenk HD, Pulverer G, Rott R, Tashiro M, Ciborowski P, Klenk HD, Pulverer G, Rott R, Tashiro M, Ciborowski P, Klenk HD, Pulverer G, Rott R

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Abstract In influenza the combined virus-bacterial pneumonia is approximately three times more common than primary viral pneumonia. The bacteria most commonly involved are Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae. S. aureus co-infection is reported to have a fatality rate of up to 42\% (ref. 2). It is thought that virus infection in the respiratory tract favours growth conditions for bacteria. In this letter data are presented which show that some S. aureus strains secrete a protease which exerts a decisive influence on the outcome of influenza virus infection in mice by cleavage activation of the virus haemagglutinin. This article was published in Nature and referenced in Clinical Microbiology: Open Access

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