alexa Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Fousteri G, Liossis SN, Battaglia M

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Abstract PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in PTPN22 are associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type 1 diabetes. This review discusses the role of PTPN22 in T and B cells, and its function in innate immune cells, such as monocytes, dendritic cells and NK cells. We focus particularly on the complexity that underlies the function of PTPN22 in the biological processes of the immune system; such complexity has led various research groups to produce rather conflicting data. © 2013 Elsevier Inc. All rights reserved. This article was published in Clin Immunol and referenced in Journal of Molecular and Genetic Medicine

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