alexa Room-temperature copper-catalyzed alpha-arylation of malonates.


Organic Chemistry: Current Research

Author(s): Yip SF, Cheung HY, Zhou Z, Kwong FY

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Abstract An effective method in targeting alpha-aryl malonates is reported. In the presence of a catalytic amount of 2-picolinic acid and CuI, the coupling of aryl iodides with diethyl malonate proceeds smoothly even at room temperature. The high levels of functional group compatibility and exceptionally mild reaction conditions offer this an attractive protocol in accessing a variety of arylated malonates. This article was published in Org Lett and referenced in Organic Chemistry: Current Research

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