Author(s): Razzaque A, Ellis BE
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Abstract Cell suspension cultures of Coleus blumei Benth. have been found to accumulate 8-11\% of their dry weight as rosmarinic acid (α-O-caffeoyl-3,4-dihydroxyphenyl-lactic acid). Actively-growing tissue converts >20\% of exogenously supplied phenylalanine and tyrosine to the caffeoyl ester and this high rate of synthesis coincides with an increase in phenylalanine ammonia-lyase specific activity. Administration to the cultures of known phenylpropanoid precursors of rosmarinic acid failed to enhance the latter's production and in some cases inhibited it.
This article was published in Planta
and referenced in Medicinal & Aromatic Plants