alexa RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Panigrahi AK, Goodman NG, Eisenberg RA, Rickels MR, Naji A,

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Abstract Continued antibody gene rearrangement, termed receptor editing, is an important mechanism of central B cell tolerance that may be defective in some autoimmune individuals. We describe a quantitative assay for recombining sequence (RS) rearrangement that we use to estimate levels of antibody light chain receptor editing in various B cell populations. RS rearrangement is a recombination of a noncoding gene segment in the kappa antibody light chain locus. RS rearrangement levels are highest in the most highly edited B cells, and are inappropriately low in autoimmune mouse models of systemic lupus erythematosus (SLE) and type 1 diabetes (T1D), including those without overt disease. Low RS rearrangement levels are also observed in human subjects with SLE or T1D.
This article was published in J Exp Med and referenced in Journal of Clinical & Cellular Immunology

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