alexa Rubella monitoring in pregnancy as a means for evaluating a possible reemergence of rubella.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Hutton J, Rowan P, Greisinger A, Mouzoon M

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Abstract OBJECTIVE: Although it is commonly accepted that rubella is well-controlled, a recent reemergence of both pertussis and measles might also predict a reemergence of rubella. This study was designed to estimate the current incidence of rubella exposure in pregnancy. STUDY DESIGN: This was a prospective, descriptive study, conducted in Houston, TX, at The Woman's Hospital of Texas. Women are typically screened for rubella immunity at the beginning of pregnancy. Rubella nonimmunity is defined as a titer less than 10 IU/mL in the US. Women who were non-immune early in pregnancy (<20 weeks) were recruited for this study and asked to be tested again for rubella immunity at the time of delivery. RESULTS: Of 298 women who were rubella nonimmune (IgG <10 IU/mL) early in pregnancy, 19 converted to immune status (IgG >40 IU/mL, defined as at least a 4-fold increase) at time of delivery, a rate of 6.38\% (4.12\% to 9.75\%; 95\% Wilson-Score confidence interval). For the 19 patients who converted to immune status at time of delivery, 8 patients had levels of 40-150 IU/mL, 6 patients had levels of 151-300 IU/mL, 2 patients had levels of 301-500 IU/mL, and 3 patients had levels >500 IU/mL. CONCLUSION: Pregnancy is a critical time to evaluate rubella exposure. This study estimated the current incidence of rubella exposure in pregnancy to be 6.38\%. Copyright © 2014 Elsevier Inc. All rights reserved. This article was published in Am J Obstet Gynecol and referenced in Journal of Vaccines & Vaccination

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