alexa Safety and effectiveness of donepezil on behavioral symptoms in patients with Alzheimer disease.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Carrasco MM, Agera L, Gil P, Morigo A, Leon T, Carrasco MM, Agera L, Gil P, Morigo A, Leon T

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Abstract The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to 10 mg/d) for 6 months. The primary outcome measure was the incidence of adverse events. Secondary outcome measures were neuropsychiatric function measured by the Neuropsychiatric Inventory (NPI), the Mini-Mental State Evaluation, and caregiver burden measured by the Zarit scale. Five hundred and twenty-nine patients were included of which 455 completed the study. The mean baseline NPI score was 19.1. Sixty-five patients (12.3\%) experienced an adverse event. The most frequent adverse events were diarrhea and agitation (<2\%). Seventeen patients (3\%) presented with a neuropsychiatric adverse event and 11 (2\%) patients presented with a neurologic adverse event over the course of the study. NPI scores improved by 34.4\% over the course of the study, with all items showing a statistically significant improvement. Mini-Mental State Evaluation scores and Zarit caregiver burden scores also improved by 1.27 points and 5.9 points, respectively. This study showed a low incidence of adverse events accompanied by an improvement in the neuropsychiatric and cognitive functions in patients with mild to moderately severe Alzheimer disease treated with donepezil in a community setting in Spain. Donepezil also reduced caregiver burden. This article was published in Alzheimer Dis Assoc Disord and referenced in Journal of Alzheimers Disease & Parkinsonism

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