alexa Safety issues related to retroviral-mediated gene transfer in humans.


Journal of Addiction Research & Therapy

Author(s): Cornetta K, Morgan RA, Anderson WF

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Abstract The first three approved human clinical trials utilizing retroviral-mediated gene transfer are now underway. While this technology holds great promise for the study and treatment of human disease, it also poses a number of safety concerns. In evaluating clinical protocols, potential complications and the likelihood of their occurrence are estimated by review committees so that a risk/benefit assessment can be made. Current knowledge, reviewed in this article, suggests that no acute complications secondary to retroviral-mediated gene transfer are likely, but the possibility of long-term or unforeseen sequelae in patients suggests the need for post-treatment monitoring. This article was published in Hum Gene Ther and referenced in Journal of Addiction Research & Therapy

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