alexa Safety of an Intravitreal Injection of Triamcinolone Results From a Randomized Clinical Trial
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Gillies MC, Simpson JM, Billson FA, Luo W, Penfold P

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Objective To determine the safety of a single intravitreal injection of triamcinoloneacetonide (4 mg) in patients with subfoveal choroidal neovascularization causedby age-related macular degeneration. Methods A double-masked, placebo-controlled, randomized clinical trial was conductedat a public tertiary referral eye hospital. Patients participating had age-relatedmacular degeneration with evidence of choroidal neovascularization, any partof which was classic; age older than 59 years; and best-corrected visual acuityof 20/200 or better. Eyes were assigned to active study treatment or to placebo.Intraocular pressure and cataract grading were performed every 6 months for3 years. Adverse events, from mild to vision-threatening or life-threatening,were recorded as procedure-related or corticosteroid-related. Results Seventy-five eyes were assigned to study treatment and 76 eyes to placebo.There were no moderate or severe adverse events related to the surgical procedurein either group. Triamcinolone-treated eyes had a significantly increasedrisk of developing mild or moderate elevation of the intraocular pressure.Topical glaucoma medication reduced intraocular pressure to acceptable levelsin all patients. There was significant progression of cataract in the triamcinolone-treatedeyes. Conclusion Despite a significant adverse event profile, intravitreal triamcinoloneis generally well tolerated by the human eye as long as patients are carefullyfollowed up by their surgeon and treated appropriately, when necessary.

This article was published in Archives of ophthalmology and referenced in Journal of Clinical & Experimental Ophthalmology

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