alexa Safety of low-dose cyclosporine therapy before transplantation in kidney allograft recipients.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Khosroshahi HT, Badrogli N, Jahannavard N, Oskuii R, Bahluli A,

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Abstract INTRODUCTION: Graft dysfunction immediately posttransplantation can vary from subtle slowing of the expected decrease in creatinine concentration to frank oliguria requiring dialysis therapy for days to weeks. Risk factors for slow and delayed graft function include prolonged preservation, older donor age, and high plasma renin activity in the recipient. Cyclosporine (CsA) nephrotoxicity is another cause of early kidney allograft dysfunction. OBJECTIVE: To evaluate early kidney allograft function in patients who received low-dose CsA therapy for 48 hours before transplant surgery for comparison with that in recipients who received CsA therapy after improvement in allograft function. PATIENTS AND METHODS: In a case-control comparative study, 66 kidney recipients were divided into 2 groups on the basis of time of initiation of CsA therapy. In group 1, patients received CsA, 100 mg twice a day, for 48 hours before surgery, and in group 2, patients received CsA therapy after surgery when allograft function had improved (serum creatinine concentration
  • DOI: 10.1016/j.transproceed.2009.06.1
  • This article was published in Transplant Proc and referenced in Journal of Clinical Toxicology

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