alexa Sample size considerations for studies comparing survival curves using historical controls.


Journal of Cancer Science & Therapy

Author(s): Dixon DO, Simon R

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Abstract Formulas are derived for determination of the number of patients needed in a prospective comparison of survival curves, when the control group patients have already been followed for some period. Although an explicit formula for the required sample size is not available, the computing is straightforward, and tables of examples are presented. Situations are described when one might need to allocate some new patients to the control group, rather than exclusively to the experimental group.
This article was published in J Clin Epidemiol and referenced in Journal of Cancer Science & Therapy

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