alexa Saponins as vaccine adjuvants
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Kensil CR

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Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte responses. This article reviews responses due to specific saponins of saponin preparations, effect of formulation, structure/function studies, and use in different preclinical and clinical vaccine applications

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This article was published in Critical Reviews™ in Therapeutic Drug Carrier Systems and referenced in Journal of Infectious Diseases & Therapy

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