alexa Scanning and transmission electron microscopic studies of microvascular pathology in the osmotically impaired blood-brain barrier.
Materials Science

Materials Science

Journal of Nanomedicine & Biotherapeutic Discovery

Author(s): Lossinsky AS, Vorbrodt AW, Wisniewski HM

Abstract Share this page

Abstract The present investigation focused on the structural events occurring in endothelial cells lining the lumina of brain microvessels in rats subjected to a single intracarotid injection of hypertonic 1.8 M L (+) arabinose solution with or without intravenous injection of horseradish peroxidase. Blood vessels from cerebral cortex and thalamus were evaluated by transmission and scanning electron microscopy. After short-term exposure (10-12 min) there was widespread flooding of peroxidase into the brain neuropil of the ipsilateral hemisphere. Peroxidase tracer was frequently observed within vesiculo-tubular profiles, and occasionally within widened interendothelial junctional clefts. Partially fragmented, necrotic endothelial cells appeared to be in the process of desquamation. Individual endothelial cells appeared to be shrunken with widened interendothelial spaces. Some healthy endothelial cells appeared to be involved in repair processes, manifested by the extension of thin cellular processes towards the area of vessel injury. Other pathological alterations included a conspicuous increase in the number of endothelial cell microvilli, large crater-like invaginations of the endothelial plasma membranes and muscular blood vessels in the process of spasm. We also observed a platelet reaction with or without endothelial cell necrosis and attached microthrombi in some arterial segments.
This article was published in J Neurocytol and referenced in Journal of Nanomedicine & Biotherapeutic Discovery

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • World Congress on Regulations of Nanotechnology
    July 31-August 01, 2017 Chicago, Illinois, USA
  • 19th Nano Congress for Next Generation
    August 31-September 01, 2017 Brussels,Belgium
  • International conference on Industrial Nanotechnology
    September 18-19, 2017 Jacksonville, Florida, USA
  • 15th World Medical Nanotechnology Congress & Expo
    October 18-19, 2017 Osaka, Japan
  • 22ndInternational Conference and Expo on Nanoscience and Molecular Nanotechnology
    Nov 13-14, 2017 Vienna, Austria
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords