Author(s): Zhang L, Strong JM, Qiu W, Lesko LJ, Huang SM
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Abstract Recently, increased interest in drug transporters and research in this area has revealed that drug transporters play an important role in modulating drug absorption, distribution, and elimination. Acting alone or in concert with drug metabolizing enzymes they can affect the pharmacokinetics and pharmacodynamics of a drug. This commentary will focus on the potential role that drug transporters may play in drug-drug interactions and what information may be needed during drug development and new drug application (NDA) submissions to address potential drug interactions mediated by transporters.
This article was published in Mol Pharm
and referenced in Journal of Analytical & Bioanalytical Techniques