Author(s): Schillaci O, Danieli R, Filippi L, Romano P, Cossu E,
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Abstract BACKGROUND: Planar scintimammography is useful for characterizing breast lesions >10 mm. Our aim was to evaluate Tc-99m sestamibi scintimammography with a hybrid (SPECTICT) device for functional anatomical mapping (FAM). PATIENTS AND METHODS: Three planar images and a chest SPECT/CT were performed with a hybrid device in 53 patients with mammographically suspicious lesions. The final histopathological diagnosis was obtained after surgery. RESULTS: The planar images were positive in 27 out of 37 carcinomas (sensitivity 73\%) and the SPECT/CT in 33 (sensitivity 89.2\%). The sensitivity of planar imaging and SPECT/CT was 42.9\% and 71.4\% in cancers < or =10 mm, and 91.3\%, and 100\% in cancers >10 mm, respectively. The specificity was 93.8\% for both planar and SPECT/CT imaging; accuracy was 79.2\% for planar scans and 90.6\% for SPECT/CT. FAM was useful in providing a precise anatomical localisation of the SPECT findings. CONCLUSION: SPECT/CT scintimammography using a hybrid device is able to detect breast cancer, showing a sensitivity higher than that of planar images, especially for small cancers.
This article was published in Anticancer Res
and referenced in Journal of Cancer Science & Therapy