alexa Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom.


Single Cell Biology

Author(s): Conde R, Zamudio FZ, Rodrguez MH, Possani LD, Conde R, Zamudio FZ, Rodrguez MH, Possani LD

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Abstract A novel peptide, scorpine, was isolated from the venom of the scorpion Pandinus imperator, with anti-bacterial activity and a potent inhibitory effect on the ookinete (ED(50) 0.7 microM) and gamete (ED(50) 10 microM) stages of Plasmodium berghei development. It has 75 amino acids, three disulfide bridges with a molecular mass of 8350 Da. Scorpine has a unique amino acid sequence, similar only to some cecropins in its N-terminal segment and to some defensins in its C-terminal region. Its gene was cloned from a cDNA library.
This article was published in FEBS Lett and referenced in Single Cell Biology

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