alexa Scrub typhus: pathophysiology, clinical manifestations and prognosis.
Infectious Diseases

Infectious Diseases

Journal of Tropical Diseases & Public Health

Author(s): Rajapakse S, Rodrigo C, Fernando D

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Abstract Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi (O. tsutsugamushi). The disease has significant prevalence in eastern and Southeast Asia. Usually presenting as an acute febrile illness, the diagnosis is often missed because of similarities with other tropical febrile infections. Many unusual manifestations are present, and these are described in this review, together with an outline of current knowledge of pathophysiology. Awareness of these unusual clinical manifestations will help the clinician to arrive at an early diagnosis, resulting in early administration of appropriate antibiotics. Prognostic indicators for severe disease have not yet been clearly established. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. This article was published in Asian Pac J Trop Med and referenced in Journal of Tropical Diseases & Public Health

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