Author(s): Dettling M, Gabrielson E, Parmigiani G
Abstract Share this page
Abstract We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.
This article was published in Genome Biol
and referenced in Advancements in Genetic Engineering